A postdoc position within formulation characterization focused on formulations for topical application to the eye is available at the Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark. The project is conducted in cooperation with Janssen Pharmaceuticals in Belgium.
The selected candidate will work with equilibrium modelling and machine learning with focus on preservation of eye drops. If preservatives interact with solubilising excipients added to make it a solution, the preservatives will lose their function – hence knowing the free fraction of preservative is key to obtaining the needed preservation. The objective of the position is therefore to develop theoretical based models to predict preservation needed in ocular formulations containing solubilising excipients, based upon chemical equilibrium theory.
Starting date: 1 December 2024 or as soon as possible thereafter.
Application deadline: 4 November 2024.
The position is available for one year.
Project background
Flux is a function of time, i.e. one way to optimize ocular drug absorption after topical administration is to increase the viscosity of the applied formulation. The viscosity would, however, slow the diffusion of the compound through the formulation, hence the purpose of the concrete project is to investigate diffusion as a function of viscosity, compound vehicle affinity and compound size for “solutions” and particle size for suspension systems.
The element in the project may include to:
• Determine stability constants for ocular preservations to relevant ocular solubilizing systems
• Define a mathematical model of competitive chemical equations in ocular formulations
• Experimentally prove the model
• Develop software interface for general applicability of models.
Besides these elements, the postdoc will be involved in a number of projects focused on data analysis if relevantly related to solubility enhancing excipients, but also related to understanding of other formulation systems.
Qualifications
We are looking for a candidate with a strong interest in working on the boundary between pharmacy and chemistry focused on defining mathematical models in Python or similar software that can be made easily available for users in the pharmaceutical industry. The candidate will hold an MSc in pharmacy, chemistry, physics, or a closely related area, and a PhD, and be able to document experience with modelling of chemical equilibriums.
The candidate must be independent and fluent in English, both oral and written.
Please see the full call, including how to apply, on www.sdu.dk.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Odense Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
Syddansk Universitet, Campusvej, 5230 Odense M
-Ansøgning:
Ansøgningsfrist: 04-11-2024;
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/6131585